Objective: To compare the pattern of familial aggregation of psychopathology in children who are good responders (GR) to methylphenidate (MPH) versus those who are poor responders (PR). Method: A total of 118 clinically referred children ages 6 to 12 years, diagnosed with ADHD participated in a double-blind, placebo-controlled, randomized 2-week…

Objective: To explore placebo-controlled efficacy and safety of atomoxetine (ATX) for attention-deficit/hyperactivity disorder (ADHD) symptoms in children with autism spectrum disorders (ASD). Method: Children ages 5 to 15 with ASD and prominent ADHD symptoms were randomly assigned to order in a crossover of clinically titrated ATX and placebo, 6…

Objective: To describe the rationale and design of the Preschool ADHD Treatment Study (PATS). Method: PATS was a National Institutes of Mental Health-funded, multicenter, randomized, efficacy trial designed to evaluate the short-term (5 weeks) efficacy and long-term (40 weeks) safety of methylphenidate (MPH) in preschoolers with…

In this article, I present a study conducted with 10 Southeastern US early childhood teachers on their views concerning problem behaviour, in general, and the practice of diagnosis and pharmaceutical treatment for Attention/Deficit Hyperactivity Disorder (ADHD), in particular. Themes that emerged from the interview data included: (1) teachers'…

There exists a strong link between ADHD and academic underachievement. Both the core behavioral symptoms of ADHD and associated executive functioning deficits likely contribute to academic impairment. Current evidence-based approaches to the treatment of ADHD (i.e., stimulant medication, clinical behavior therapy and classroom behavioral…

This column focuses on the valid, reliable, and useful measurement of treatment effects in children and adolescents with attention-deficit/hyperactivity disorder (ADHD) treated in practice settings. The case is presented of Polly, an 11 year-old female who was evaluated and determined to have probably met diagnostic criteria for ADHD, combined…

Presents both sides of this controversial issues, concluding that to provide consistency for students with attention deficit hyperactivity disorder in all environments, parents and educators must cooperatively plan interventions, researching and evaluating valid information about various forms of treatment before deciding to use medication. The…

In this study we conducted single-case analyses of the dosage and time-course effects of methylphenidate (MPH; Ritalin) on disruptive classroom behavior, math and reading performance, and social engagement. Clear individual differences were demonstrated (a) across children; (b) across academic, behavioral, and social domains of functioning; (c)…

Objective: The purpose of this study was to examine the efficacy of psychostimulant medication in a naturalistic sample of preschoolers. Benefits and side effects for methylphenidate and mixed amphetamine salts (Adderall) were examined. Method: Twenty-eight preschoolers (ages 4.0-5.9) participated in the present investigation. They were obtained…

We used an assessment that involved competing reinforcer dimensions in a concurrent-schedules arrangement to examine the effects of stimulant medication on impulsivity (i.e., sensitivity of choices to reinforcer immediacy relative to rate, quality, and effort) with 4 students with attention deficit hyperactivity disorder. The assessments were…

Background: Recent studies reported ADHD-like symptoms and cognitive deficits in pervasive developmental disorder (PDD). Because work in dementia documents improvement in executive function deficits with the acetylcholinesterase inhibitor donepezil, the authors reason that similar benefits could be obtained in PDD. Method: The authors describe…

Debate continues over the hypothesis that children with language or literacy difficulties have a genuine auditory processing deficit. Several recent studies have reported deficits in frequency discrimination (FD), but it is unclear whether these are genuine perceptual impairments or reflective of the comorbid attentional problems that exist in…

This study explored the use of methylphenidate with two boys (ages 7 and 8 years) with Williams syndrome, a genetic disorder frequently accompanied by symptoms associated with Attention Deficit Hyperactivity Disorder (ADHD). Both boys performed optimally on 10 mg of methylphenidate administered twice daily, although one displayed increased…

In response to Robert Cooter, Jr. (EC 202 670), who questioned the widespread use of Ritalin with children having attention deficit hyperactivity disorders, this commentary considers four specific points: how Ritalin works, Ritalin's side effects and relationship to Tourette syndrome, the assumption that Ritalin leads to drug abuse, and the…

Reviews studies examining effects of pharmacological interventions for children with mental retardation and autism. Discusses information regarding stimulants, neuroleptics, anticonvulsants, antianxiety drugs, and antidepressant drugs as measured by their effects on laboratory and clinical measures of activity level, self-injurious behavior, and…