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Consensus Report on Impulsive Aggression as a Symptom across Diagnostic Categories in Child Psychiatry: Implications for Medication Studies
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Jensen, Peter S.; Youngstrom, Eric A.; Steiner, Hans; Findling, Robert L.; Meyer, Roger E.; Malone, Richard P.; Carlson, Gabrielle A.; Coccaro, Emil F.; Aman, Michael G.; Blair, James; Dougherty, Donald; Ferris, Craig; Flynn, Laurie; Green, Evelyn; Hoagwood, Kimberly; Hutchinson, Janice; Laughren, Tom; Leve, Leslie D.; Novins, Douglas K.; Vitiello, Benedetto – Journal of the American Academy of Child & Adolescent Psychiatry, 2007
Objective: To determine whether impulsive aggression (IA) is a meaningful clinical construct and to ascertain whether it is sufficiently similar across diagnostic categories, such that parallel studies across disorders might constitute appropriate evidence for pursuing indications. If so, how should IA be assessed, pharmacological studies…
Descriptors: Psychiatry, Public Health, Ethics, Clinical Experience
Atomoxetine for Hyperactivity in Autism Spectrum Disorders: Placebo-Controlled Crossover Pilot Trial
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Arnold, L. Eugene; Aman, Michael G.; Cook, Amelia M.; Witwer, Andrea N.; Hall, Kristy L.; Thompson, Susan; Ramadan, Yaser – Journal of the American Academy of Child and Adolescent Psychiatry, 2006
Objective: To explore placebo-controlled efficacy and safety of atomoxetine (ATX) for attention-deficit/hyperactivity disorder (ADHD) symptoms in children with autism spectrum disorders (ASD). Method: Children ages 5 to 15 with ASD and prominent ADHD symptoms were randomly assigned to order in a crossover of clinically titrated ATX and placebo, 6…
Descriptors: Hyperactivity, Autism, Drug Therapy, Attention Deficit Disorders
Evaluation of Pharmacological Treatment of Impulsivity in Children with Attention Deficit Hyperactivity Disorder
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Neef, Nancy A.; Bicard, David F.; Endo, Sayaka; Coury, Daniel L.; Aman, Michael G. – Journal of Applied Behavior Analysis, 2005
We used an assessment that involved competing reinforcer dimensions in a concurrent-schedules arrangement to examine the effects of stimulant medication on impulsivity (i.e., sensitivity of choices to reinforcer immediacy relative to rate, quality, and effort) with 4 students with attention deficit hyperactivity disorder. The assessments were…
Descriptors: Reinforcement, Pharmacology, Stimulants, Hyperactivity
Fenfluramine and Methylphenidate in Children with Mental Retardation and Borderline IQ: Clinical Effects.
And Others; Aman, Michael G. – American Journal on Mental Retardation, 1997
A double-blind, placebo-controlled, crossover study of methylphenidate and different doses of fenfluramine in 30 children (ages 5-14) with mental retardation or borderline IQ and attention deficit hyperactivity disorder was conducted. Parents and teachers cited more improvement with fenfluramine; however, fenfluramine had more side effects,…
Descriptors: Anorexia Nervosa, Attention Deficit Disorders, Children, Drug Therapy
Fenfluramine and Methylphenidate in Children with Mental Retardation and Attention Deficit Hyperactivity Disorder: Laboratory Effects.
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Aman, Michael G.; And Others – Journal of Autism and Developmental Disorders, 1993
Twenty-eight children (ages 5-13) with mental retardation, hyperactivity, and inattentiveness were administered fenfluramine and methylphenidate. Fenfluramine was superior to placebo on the memory task, whereas methylphenidate reduced commission errors on a continuous performance test. Methylphenidate caused shorter response times whereas…
Descriptors: Attention Deficit Disorders, Drug Therapy, Hyperactivity, Memory
Prediction of Clinical Response in Children Taking Methylphenidate.
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Aman, Michael G.; Turbott, Sarah H. – Journal of Autism and Developmental Disorders, 1991
Twenty-six children (ages 5-12) with attention deficit hyperactivity disorder were tested before and after treatment with methylphenidate. Few performance tests predicted clinical response to medication. Chronological age and performance on a memory distraction task and the Graduated Holes Task were moderately correlated with clinical outcome.…
Descriptors: Attention Deficit Disorders, Behavior Rating Scales, Drug Therapy, Elementary Education
Pharmacotherapy for Hyperactivity in Children with Autism and Other Pervasive Developmental Disorders.
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Aman, Michael G.; Langworthy, Kristen S. – Journal of Autism and Developmental Disorders, 2000
A review of 41 studies on pharmacological treatments for children with autism and pervasive personality disorder not otherwise specified, found empirical evidence for significant reductions in hyperactive symptoms was strongest for the antipsychotics, psychostimulants, and naltrexone. A theoretical model is proposed for using attentional…
Descriptors: Attention Deficit Disorders, Attention Span, Children, Drug Therapy
Four-Year Follow-Up of Children with Low Intelligence and ADHD: A Replication.
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Aman, Michael G.; Armstrong, Sharon; Buican, Brett; Sillick, Traci – Research in Developmental Disabilities, 2002
Twenty children with attention deficit hyperactivity disorder (ADHD) and low IQs were followed up 4.5 years later (ages 8-20). A majority continued to screen positive for ADHD, as well as display high rates of comorbid anxiety disorders, tics, and elimination disorders. Multiple medication trials resulted in significantly lower hyperactivity…
Descriptors: Adolescents, Age Differences, Anxiety, Attention Deficit Disorders