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Peer reviewed
Direct linkAbraham, Antony D.; Cunningham, Christopher L.; Lattal, K. Matthew – Learning & Memory, 2012
Methylphenidate (MPH, Ritalin) is a norepinephrine and dopamine transporter blocker that is widely used in humans for treatment of attention deficit disorder and narcolepsy. Although there is some evidence that targeted microinjections of MPH may enhance fear acquisition, little is known about the effect of MPH on fear extinction. Here, we show…
Descriptors: Animals, Attention Deficit Disorders, Patients, Drug Therapy
Niederhofer, Helmut – Journal of Attention Disorders, 2012
Objective: Agomelatine is a relatively new antidepressant, with affinities to MT1 and MT2 (responsible for the circadian rhythm) as well as to 5-HT2C receptors. Since antidepressants have demonstrated some benefit in the treatment of ADH and because of the fact, that ADHD is often associated with sleep disorders, we assumed, that it might be a…
Descriptors: Sleep, Attention Deficit Disorders, Drug Therapy, Symptoms (Individual Disorders)
Faraone, Stephen V.; Spencer, Thomas J.; Kollins, Scott H.; Glatt, Stephen J.; Goodman, David – Journal of Attention Disorders, 2012
Objective: To explore dose-response effects of lisdexamfetamine dimesylate (LDX) treatment for ADHD. Method: This was a 4-week, randomized, double-blinded, placebo-controlled, parallel-group, forced-dose titration study in adult participants, aged 18 to 55 years, meeting "Diagnostic and Statistical Manual of Mental Disorders" (4th ed., text rev.)…
Descriptors: Attention Deficit Disorders, Rating Scales, Severity (of Disability), Drug Therapy
Davari-Ashtiani, Rozita; Shahrbabaki, Mahin Eslami; Razjouyan, Katayoon; Amini, Homayoun; Mazhabdar, Homa – Child Psychiatry and Human Development, 2010
The efficacy and side effects of buspirone compared with methylphenidate (MPH) in the treatment of children with attention-deficit/hyperactivity disorder (ADHD). A total of 34 children with ADHD as defined by DSM-IV-TR were randomized to buspirone or methylphenidate dosed on weight-adjusted basis at buspirone (0.5 mg/kg/day) and methylphenidate…
Descriptors: Attention Deficit Hyperactivity Disorder, Attention Deficit Disorders, Rating Scales, Drug Therapy
Grizenko, Natalie; Paci, Michael; Joober, Ridha – Journal of Attention Disorders, 2010
Objective: To compare the ADHD combined/hyperactive subtype (ADHD/CH) to the ADHD inattentive subtype (ADHD/I) on the level of comorbidity, treatment response, and possible etiological factors. Method: A total of 371 clinically referred children diagnosed with ADHD aged between 6 and 12 years are recruited for a double-blind, placebo-controlled…
Descriptors: Body Weight, Mothers, Drinking, Pregnancy
Download full textChuang, Tsung-Yen; Lee, I-Ching; Chen, Wen-Chih – Online Submission, 2010
ADHD or ADD (Attention Deficit/Hyperactivity Disorder) is one of the most frequently diagnosed mental and behavioral disorders of children. Children with ADHD are characterized by poor attention and distractibility and/or hyperactive and impulsive behaviors. Although there is no "cure" for ADHD, there are accepted treatments that…
Descriptors: Behavior Disorders, Attention Deficit Hyperactivity Disorder, Child Behavior, Attention Span
McRae-Clark, Aimee L.; Brady, Kathleen T.; Hartwell, Karen J.; White, Kathleen; Carter, Rickey E. – Journal of Attention Disorders, 2011
Objective: This 8-week, open-label trial assessed the efficacy of methylphenidate transdermal system (MTS) in 14 adult individuals diagnosed with ADHD and with a history of stimulant misuse, abuse, or dependence. Method: The primary efficacy endpoint was the Wender-Reimherr Adult ADHD Scale (WRAADS), and secondary efficacy endpoints included the…
Descriptors: Stimulants, Substance Abuse, Attention Deficit Disorders, Drug Therapy
DuPaul, George J.; Weyandt, Lisa L.; Rossi, Joseph S.; Vilardo, Brigid A.; O'Dell, Sean M.; Carson, Kristen M.; Verdi, Genevieve; Swentosky, Anthony – Journal of Attention Disorders, 2012
Objective: To evaluate stimulant medication on symptoms and functioning for college students with ADHD using double-blind, placebo-controlled, crossover design. Method: Participants included 24 college students with ADHD and 26 college students without psychopathology. Lisdexamfetamine dimesylate (LDX) was examined for ADHD participants over five…
Descriptors: College Students, Stimulants, Attention Deficit Disorders, Psychopathology
Palumbo, Donna R.; Sallee, Floyd R.; Pelham, William E., Jr; Bukstein, Oscar G.; Daviss, W. Burleson; McDermott, Michael P. – Journal of the American Academy of Child & Adolescent Psychiatry, 2008
A study to examine the effectiveness and tolerance of clonidine alone or in combination with methylphenidate as a mode of treatment of attention-deficit/hyperactivity disorders is conducted. Results indicate methylphenidate as the most effective in treatment as compared to clonidine, which was well tolerated.
Descriptors: Hyperactivity, Attention Deficit Disorders, Drug Therapy, Outcomes of Treatment
Bloch, Michael H.; Panza, Kaitlyn E.; Landeros-Weisenberger, Angeli; Leckman, James F. – Journal of the American Academy of Child & Adolescent Psychiatry, 2009
Methylphenidate appears to provide the greatest and most immediate improvement of the symptoms of attention deficit hyperactivity disorder and does not appear to worsen tic symptoms based on a meta-analysis study. The meta-analysis included nine studies with 477 subjects.
Descriptors: Hyperactivity, Attention Deficit Disorders, Meta Analysis, Neurological Impairments
Wilens, Timothy E.; Boellner, Samuel W.; Lopez, Frank A.; Turnbow, John M.; Wigal, Sharon B.; Childress, Ann C.; Abikoff, Howard B.; Manos, Michael J. – Journal of the American Academy of Child & Adolescent Psychiatry, 2008
A study investigated the impact of variable wear times of the methylphenidate transdermal system in children with attention-deficit/hyperactivity disorder (ADHD). It was concluded that duration of medication effect was directly related to the wear time of the methylphenidate transdermal system patch.
Descriptors: Hyperactivity, Attention Deficit Disorders, Children, Drug Therapy
Daviss, W. Burleson; Patel, Nick C.; Robb, Adelaide S.; McDermott, Michael P.; Bukstein, Oscar G.; Pelham, William E., Jr.; Palumbo, Donna; Harris, Peter; Sallee, Floyd R. – Journal of the American Academy of Child & Adolescent Psychiatry, 2008
A study to examine the safety and tolerance of clonidine, alone or with methylphenidate as a form of treatment in children with attention-deficit/hyperactivity disorders (ADHD) is conducted. Results conclude that clonidine used alone or in combination with methylphenidate were safe and well tolerated in children with ADHD.
Descriptors: Hyperactivity, Attention Deficit Disorders, Drug Therapy, Outcomes of Treatment
Spencer, Sarah V.; Hawk, Larry W., Jr.; Richards, Jerry B.; Shiels, Keri; Pelham, William E., Jr.; Waxmonsky, James G. – Journal of Abnormal Child Psychology, 2009
Recent research has suggested that intra-individual variability in reaction time (RT) distributions of children with ADHD is characterized by a particularly large rightward skew that may reflect lapses in attention. The purpose of the study was to provide the first randomized, placebo-controlled test of the effects of the stimulant methylphenidate…
Descriptors: Stimulants, Reaction Time, Attention Deficit Disorders, Hyperactivity
Mahon, Anthony D.; Stephens, Brooke R.; Cole, Andrew S. – Journal of Attention Disorders, 2008
Objective: The effect of stimulant medication on exercise responses was studied in 14 boys (10.9 plus or minus 1.1 years) with attention deficit/hyperactivity disorder (ADHD). Method: Exercise, with and without medication, was performed at 25 W, 50 W, and 75 W, followed by a peak exercise test. Result: Submaximal heart rate (HR) was significantly…
Descriptors: Metabolism, Stimulants, Hyperactivity, Attention Deficit Disorders
Whalen, Carol K.; Henker, Barbara; Ishikawa, Sharon S.; Emmerson, Natasha A.; Swindle, Ralph; Johnston, Joseph A. – Journal of Attention Disorders, 2010
Objective: To compare the morning and afternoon/evening functioning of children with ADHD treated in the community with either atomoxetine or long-acting stimulants and reported to be doing well. Method: 109 8- to 12-year-olds and their mothers participated in one of three groups: stimulants (STIM, N = 26), atomoxetine (ATMX, N = 25), or…
Descriptors: Stimulants, Mothers, Hyperactivity, Attention Deficit Disorders
