Preliminary investigations reveal that some academic staff find it difficult to adapt use of e-learning facilities for delivery academic duties which could lead to job ineffectiveness. The study, investigated the extent to which e-learning facilities availability, usability and adaptability predict job effectiveness among academic staff of University of Ibadan in order to ensure effective delivery of academic duties. Non-experimental design of correlational research type was adopted. Population comprised lecturers in Faculties, Institutes and Centres in University of Ibadan. Purposive sampling technique was used to select 14 Faculties (48 Departments), 3 Institutes and 2 Centres which are academic units. Five lecturers were randomly selected in each unit, given sample of 265 lecturers. Data was collected using four instruments developed and content validated and ordinal alpha reliability estimated. Three research questions were raised. Data analysis was done using PPMC and Multiple regression. Results showed that availability, usability and adaptability of e-learning facilities had positively significant influence on job effectiveness among academic staff of the University of Ibadan. The study recommended that academic staff should adapt the use of e-learning facilities into their academic work to enhance job effectiveness.