This study explored the perceived benefits and challenges that Natural Sciences teachers experience when using blended teaching in Smart Schools. This qualitative research focused on public township schools with challenging socio-economic contexts in the Gauteng Province, South Africa. A non-probability purposive sampling method was followed. The data collection technique used involved individual, face-to-face, semi-structured interviews. Interviews conducted with 10 Natural Sciences teachers were analysed through inductive analysis. The key findings of this study portrayed that teachers perceived that the incorporation of blended teaching and learning presented major pedagogical benefits, such as increased learner enjoyment and improved engagement as visual enhancements of the scientific processes and concepts aid learning, save teaching and reduce learning time since complex scientific concepts are simplified and use virtual experiments instead of traditional hands-on practicals. Efficiency in long-term running costs was seen as another benefit. According to these Natural Science teachers, one disadvantage in particular was an increased workload owing to double lesson planning for classroom activities and particularly for science practicals with and without the use of smart equipment, where there were external challenges such as load shedding, inoperable devices, connectivity challenges and/or smart equipment thefts. It is recommended that Smart School teachers are encouraged to form communities of practice to share strategies to minimise the perceived or experienced challenges in blended teaching.