In this paper we propose i-SERF (integrated-Self Evaluated and Regulated Framework) an integrated self-evaluated and regulated framework, which facilitates synchronous and asynchronous education, focusing on teaching and learning in higher education. The i-SERF framework is a two-layered framework that takes into account various elements of existing frameworks, introducing though as a new element the means of a self-evaluation, self-feeding and regulation mechanism. This mechanism is based on the performance of students, on the students' answers to appropriately structured questionnaires and on the online monitoring of the supporting platform's parameters. The outcome derived from a "self-evaluation" process is then feeding i-SERF in order to obtain self-regulation, for the next deployment. In this way, i-SERF remains alive and progressing. The proposed framework aims to offer the needed background for designing Web 2.0 educational platforms that may exhibit continuous improvement functions, providing in that way considerable benefits to both students and tutors in various fields. A pilot implementation, using an education-oriented suite with enriched interactive elements supporting a variety of terminal devices, combined with a thorough assessment that utilizes advanced statistical tools has revealed the potentials of the platform to successfully deploy the principles of the i-SERF framework to yield powerful learning experiences and high quality interactions between students and teachers.