This paper describes the development of a taught Master's course in biomedical diagnostics using a novel multi-disciplinary approach. This course, the first of its kind in Ireland, covers the science and technology underlying the development of medical diagnostic devices that detect early markers of diseases such as cancer. The ethical impact of these devices on society, the importance of scientific communication, relevant aspects of business entrepreneurial studies and the commercialisation of medical devices are also covered. The course consists of a mixture of theory, intensive laboratory practicals and independent research. The challenges faced in setting up and running the course are described, as well as some of the novel aspects and may provide valuable insight to those involved in the development of high-level Master's courses. (Contains 2 figures and 2 tables.)