Learning the wealth of information in metabolic pathways is both challenging and overwhelming for students. A step-by-step guided discovery approach to the learning of the chemical steps in gluconeogenesis and the citric acid cycle is described. This approach starts from concepts the student already knows, develops these further in a logical manner using easy-to-remember memory devices, and significantly reduces student learning demand. This approach incorporates the use of PowerPoint, web access, and a digital whiteboard to enhance student learning and retention.