One of the most challenging aspects of teaching anatomy and physiology is using teaching tools that enhance active learning and keep students actively engaged during the lecture courses. This study explored the use of a student response system that was easy to use, cost-efficient, and re-usable for multiple anatomy and physiology courses. More specifically, the impact of i>clickers on student performance in anatomy and physiology courses was investigated by comparing exam scores before and after the introduction of i>clickers. This study showed that the use of i>clickers during the lecture courses increased student engagement and improved the performance of students on the lecture exams covering the respiratory, digestive, urinary, reproductive, lymphatic, and immune systems. The overall performance of students in the anatomy and physiology lecture courses had also a tendency to increase. Furthermore, student feedback regarding i>clicker use was highly positive.