The purpose of this study was to examine coping against weight-related teasing among adolescents perceived to be overweight or obese in urban physical education. Forty-seven students perceived to be overweight or obese from a large urban school district were interviewed. Trustworthiness of data analysis was established by using a member-checking procedure, focus group interview, and peer debriefing throughout the research process. The results indicated that adolescents perceived to be overweight or obese used self-protection, compensation, confrontation, seeking social support, avoidance/psychological disengagement, losing weight and stress reduction strategies to cope against weight-related teasing. Adolescents used multiple strategies under different mechanisms to cope, and the strategies they chose were dependent on the situation.