Science curricula often guide us to teach students just the facts, but our students need to be prepared for life in the 21st century. Since technology is developing rapidly, we do not know what new technologies, resources, and information our students will be working with when they complete school. If we want our students to be truly prepared for life in the 21st century, we need to prepare them to approach the world with creative scientific skills. This article discusses the importance of creative thinking in science and includes activities that can be structured to support the development of your students' creative scientific skills both in and out of the classroom. (Contains 4 figures and 8 online resources.)