Stress remains the number one health concern among college students today; therefore, research on student stress is imperative, from both an organizational and an individual perspective. This research study explored the moderating role of coping skills on the relationship between self-leadership and stress among college students. Using the ALSQ, PSS, and BCI, a survey was administered to full-time undergraduate students attending a four-year public university in the mid-Atlantic region. A total of 643 responses were received, and the data was analyzed using a moderated regression model. The results indicated self-leadership practices reduce student stress levels and a positive relationship with coping and stress was discovered. The findings from this study deepen the understanding of how self-leadership practices significantly decrease student stress. This study raises awareness about the issue of student stress and showcases self-leadership as being an effective tool at reducing stress. Furthermore, this study provides an opportunity for college students to recognize that they have the ability to lead themselves through stressful situations and should incorporate self-leadership practices. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]