The present study investigates the association of parenting and family factors with nonsuicidal self-injury (NSSI) in preadolescents. A sample of 1,439 preadolescents and their parents were assessed by means of (a) adolescent-reported parenting behaviors (support and behavioral/psychological control), (b) parent-reported parenting behaviors (support and behavioral/psychological control) and parenting stress, and (c) parent-reported family structure, socioeconomic status (SES) of the family, family functioning, and family stressful life-events. The prevalence of NSSI was 4.82%. Preadolescents engaging in NSSI perceived more psychological and behavioral control from their parents. Logistic regression using parent-reported parenting behaviors as covariates showed a significant interaction between parent-reported support and behavioral control in relation to NSSI behaviors. No significant differences in parent-reported parenting stress and family structure emerged. Significant differences in parent-reported SES of families with and without self-injurious preadolescents were found. Finally, no significant associations appeared between the presence of NSSI and parent-reported family functioning and stressful life-events.