Research in the area of public stigma and Alzheimer disease (AD) is attracting increased attention in the last years. However, studies are limited to assessing the topic among adult persons. The aims of this study were to assess stigmatic beliefs toward a person with AD in high-school students and to examine whether majority-minority status is associated with stigmatic beliefs beyond other correlates of stigma. A total of 460 high-school students aged 14-15 participated in the study. Approximately half (55.1%) were female and the rest male. The majority of participants were Jewish (64.6%) and the rest were Israeli Arabs. Students completed a self-administered structured questionnaire assessing public stigma, ageism, knowledge about AD, and familiarity with AD. Results showed that high-school students reported relatively low levels of stigmatic beliefs toward a person with AD. Additionally, the majority- minority status had a unique contribution to the explanation of stigma, with Arab high-school students reporting higher levels of stigma toward a person with AD in comparison to Jewish students. Our results stress the importance of developing intervention programs to reduce stigma toward persons with AD at an early age. These programs should be tailored to the cultural values and needs of specific groups.