The study is based on an implementation of the basic steps of the Change Laboratory methodology (Engeström, Virkkunen, Helle, Pihlaja & Poikela, 1996) at the University of Ioannina. It was derived by a discussion with master's students during a course about science education curricula in pre-school and primary education and their effectiveness in the current educational system. Students' engagement in Science Education is a multifaceted and complex process. Under a socio-cultural approach it constitutes an activity system which consists of several elements and as a whole, is interconnected and interacting with more activity systems which interfere in the process. The element that connects all the above systems is the shared object which in the case we are studding is the enhancement of teachers' confidence in teaching science education. The developmental work research methodology (Virkkunen & Newnham, 2013; Engestrom, 2015) was chosen in order the participants to reflect on the current activity, to identify the contradictions of the activity and propose solutions forming a new model. Within this implementation Engestrom's triangular model of the Activity system (2001) is deployed and qualitative research methods are applied to analyze the content of the CL sessions occurred among participants. The findings of this study attempt to examine the challenges of the participating teachers in teaching science education and how their confidence can be enhanced and furthermore, the CL methodology as a tool in professional development.