The main purpose of this study is to verify and understand the effects of IT integration into teaching by colleges and vocational schools in Taiwan on learning effectiveness, with learning satisfaction as a mediator. This paper adopts stratified sampling on the administrative supervisors and teachers (i.e. population) in Taiwanese colleges and vocational schools. Structural equation modelling (SEM) is performed to verify the overall model and goodness-of-fit of the structural model and the measurement model. The research results suggest: (1) IT integration into teaching yields significantly positive influence on learning effectiveness; (2) IT integration into teaching exhibits significantly positive influence on learning satisfaction; and (3) Learning satisfaction has a significantly positive influence on learning effectiveness. In sum, learning satisfaction exhibits a certain degree of mediating effects. The research findings can serve as a reference to the administrative supervisors and teachers in Taiwanese colleges and vocational schools regarding the importance and benefits of IT integration into teaching to learning satisfaction and learning effectiveness of students.