Problem-solving is a skill of fundamental importance for populations with developmental delays, and especially for students with Autism Spectrum Disorder (ASD). Training students with ASD to solve ill-defined problems is a challenging objective for educational and therapeutic teams. This is due to the myriad of unpredictable situations presented during the school day and the various responses, socially appropriate or inappropriate, that may be emitted to solve one's problem. The purpose of this paper is to present a systematic clinical behavioral program named the Problem Solver (PS) specifically designed to teach problem-solving to high-functioning students with ASD. The authors detail the three stages of the PS program (i.e., determining a set of problems and solutions for each student, skill acquisition and practice, and implementation of whole-class token economy). The authors conclude with recommendations for successful implementation in school settings.