This systematic review of the literature provides a synthesis of research on the use of technology to support sign language. Background research on the use of sign language with students who are deaf/hard of hearing and students with low incidence disabilities, such as autism, intellectual disability, or communication disorders is provided. The practice of utilizing technology incorporating sign language to promote language development, reading comprehension, and writing in sign language users is examined. Also, use of technology to learn sign language is investigated. In addition, the implications for rural educators are discussed. Based on the review, a resource of technology applications is provided for parents, interpreters, and teachers to implement at home or in the rural classroom.