The four B's framework described in this article grew out of the authors' global study of "collaborative professionalism" (Hargreaves & O'Connor, 2017, 2018). They define collaborative professionalism as ways educators work together with depth, trust, and precision to achieve impact. The authors then set out to study how it manifests in different cultures and countries. As they looked across different settings, they found that particular designs for collaborating, like lesson study or teacher-led learning communities, seemed to work brilliantly in one culture or context but had features that might not work as well or in the same way in other contexts. This article provides a summary of what educators need to know about the conditions for success according to four B's: What was happening "before," "beside," "beyond", and "betwixt" the collaboration.