The study utilized African theories, literatures, framework and a qualitative method with 11 heterosexual Nigerian undergraduate university students to explore their perceptions and attitudes towards homosexuality and LGB persons. The data analysis identified six categories: (a) higher tolerance observed for lesbians than gay men among heterosexual men; (b) possibility of biological causation of homosexuality; (c) assumptions of social and environmental factors as influencing homosexuality; (d) assumption that gays are sexual abusers and the fear of gay men and lesbians; (e) positive perceptions about LGB persons; and (f) suggestions on conversion therapy for LGB persons. This study identifies perceptions, attitudes and microaggressions of heterosexual students towards LGB persons and the implications on safe schools and the well-being of LGB students. The study recommends how to address heterosexism and homophobia in our schools and campuses. Findings are discussed with findings on attitudes towards homosexuality in schools and universities in some African countries.