In the context of England, secondary biology education is dominated by sub-organismal systems, such as physiology, often to the detriment of evolution & ecology and impeding an integrated understanding of biology. This paper proposes a framework that teachers could use to help them consider how the learning of physiological and developmental systems can be combined with ecological and evolutionary thinking. Thus, keeping a balance between anthropomorphic contexts, and those of nature. The framework has two axes: physio-developmental -- ecology, and contemporary -- evolutionary, from which four quadrants emerge for consideration during topic design. It is proposed that topic design in general should be centred on the whole organism in its environment, which would ensure that physiological phenomena are contextualised in the organism's ecology. Furthermore, it is proposed that by pedagogical use of comparative biology, an evolutionary perspective can be integrated with organismal systems and ecology, whilst also offering more opportunities for students to discern the pattern being studied and be exposed to more non-human organisms. The framework is designed for practising teachers and would not require a radical change in pedagogy or teaching resources, but a new way of seeing the content and organisation of the course.