Preterm birth consequences may lead to developmental deficits, psychiatric disorders and may also cause parental mental health problems. Our aim was to describe quality of life and internalizing-externalizing behaviours of preterm children at 2 years regarding parental mental health. 112 mothers of preterm children provided the following information: pediatric quality of life, internalizing-externalizing behaviours, maternal perceived stress, anxiety, depression and satisfaction with life. Regarding emotional and behavioural problems and low quality of life, risk factors are lower birthweight, neonatal morbidities and lower socioeconomic status. Mothers with higher stress, more anxiety and depression symptoms and lower satisfaction with life reported more internalizing-externalizing behaviours and lower quality of life about their children. Among low birthweight children, conduct and hyperactivity problems are the most common at 2 years old. We emphasize the importance of parental mental health and the need for early prevention and intervention in order to minimalize the burden of hyperactivity symptoms.