Social support and positive activity involvement are considered protective factors that can help offset the risks for youths living in impoverished areas. This study investigated whether insufficient social support and activity involvement are related to internalizing difficulties, such as depression, anxiety, loneliness, and low self-esteem. Multiple levels of social support and activity involvement were examined, including family, school, and community. The study sample consisted of sixth-grade African American youths living in a disadvantaged community. Univariate and bivariate analyses showed that almost one-quarter of the youths reported they experienced depression, social anxiety, and low self-esteem but not loneliness, and those who experienced one internalized difficulty were prone to experiencing others. Findings from correlation analyses suggest that youths who lack family social support and do not participate in family activities seem likely to experience one or more internalized difficulty. Surprisingly, insufficient school and community social support and activity involvement were not related to experiencing depression, anxiety, loneliness, or low self-esteem.