The stimulus pairing observation procedure (SPOP) combined with multiple exemplar instruction (MEI) has been shown to be effective with typically developing preschoolers in establishing the joint stimulus control required for the development of naming. The purpose of the current investigation was to evaluate the effectiveness and efficiency of the SPOP in establishing speaker and listener responses in children with autism. Participants were presented with pairings of auditory and visual stimuli during instruction. Participants' tacting and listener responses of the visual stimuli were then evaluated during a test phase. MEI with novel pairs of auditory and visual stimuli was conducted if participants did not demonstrate criterion performance on tact and listener probes. SPOP in conjunction with MEI was shown to be effective in establishing some of the tact and listener relations for the three participants. However, accuracy on tact probes was always lower than listener probes. The participant who responded with the highest accuracy on untaught tact and listener probes also displayed echoic responding on the lowest proportion of SPOP instruction and listener test trials.