Background: The incidence of diabetes in Latinos is 12.8% compared to 9.3% of the general population. Latinos suffer from a higher prevalence of diabetic complications and mortality than whites yet receive less monitoring tests and education. Purpose: (1) Identify changes in clinical indicators among subjects with type 2 diabetes participating in the Emory Latino Diabetes Education Program (ELDEP), (2) identify changes in risk reduction examinations, and (3) describe the independent contribution of sociodemographic characteristics and biomedical indicators as predictors of class return. Methods: A quasi-experimental study was conducted over 5 years in Latinos with type 2 diabetes mellitus. One hundred forty-two patients receiving culturally appropriate diabetes self-management education and support (DSME/S) were included from 7 primary care clinics in Georgia. Questionnaires and biomedical markers were collected at baseline and 3-month follow-up. Results: Results from this study show that A1C was lowered from 9.1% at baseline to 7.8% at follow-up (P < 0.001), blood pressure decreased from 135/85 to 128/79 mmHg (P < 0.001), and home blood glucose monitoring increased from 63% to 85% (P < 0.001). Risk-reduction examinations increased significantly from baseline to follow-up. Predictors of attendance for DSME/S classes were income, physical activity, and previous class attendance (P < 0.05). Discussion: ELDEP was effective in providing DSME/S, decreasing biomedical markers, and increasing risk reduction examinations. Translation to Health Education Practice: Exploring culturally appropriate, community-based interventions to foster engagement in follow-up care may be useful in improving diabetes self-management in Latinos.