Past research has drawn attention to the unique challenges for students of color attending predominantly white colleges and universities, yet few have focused on the classroom as a micro-context in which race-related discussions often occur. Using a focus group methodology, 22 African American undergraduate students from a variety of academic programs shared their past experiences with classroom discussions about race. Thematic analyses revealed that African American students' cognitive and emotional responses to race-focused discussions in the classroom were uniquely shaped by the broader context of attending a predominantly White university situated in a Midwestern region of the United States. Students' responses gave insights into the strategies that minority students use to navigate race-focused discussions in class and the impact that those strategies have on their class participation. The implications of our results for students and faculty, particularly those situated on predominantly White campuses, are discussed.