Background: Latinos in the United States are at heightened risk for obesity and health disparities, yet community-based interventions to promote health are limited. Purpose: This research examined the feasibility and efficacy of a culturally relevant obesity prevention program (Vivir Sano), which included stress reduction and behavioral lifestyle intervention components. Methods: In phase 1, focus groups were completed with 21 residents of an affordable housing community to assess program needs and interests. In phase 2, 41 primarily Latino adults living in several neighboring affordable housing communities enrolled in the intervention. Twenty-three (56%) completed both pre- and postassessments (per protocol group). We examined pre-post differences in health-related behaviors, knowledge, and attitudes. Results: Over 96% of participants who completed a posttest satisfaction questionnaire reported that they were likely or very likely to use the skills learned in the program. Approximately 85% reported that the program moderately or significantly improved their health. An analysis of variance (ANOVA) indicated that the per protocol group increased weekly vegetable consumption by 4.2 servings (Cohen's "d" = 0.48). Translation to Health Education Practice: We discuss barriers and lessons learned related to implementing obesity prevention programming in affordable housing communities, where residents are more likely to experience chronic stress and food insecurity.