For Alaskan Indigenous people, an acute clash of cultures occurs daily in U.S. public school education. The dynamics used to implement and improve the well-being and graduation outcomes for Alaska Native youth in urban public school are presented. A partnership between Cook Inlet Tribal Council, Inc., an Alaska Native social service nonprofit, and the Anchorage School District serves as a model of success, acknowledged by both the George W. Bush and Obama presidential administrations as an exemplary collaboration between a tribal organization and a public school system. The program detailed in this article enabled a systemic change and developed a strengths-based best practice that resulted in an academically rigorous, culturally responsive, engaging, and empowering opportunity for Alaska Native students in public school. Such a program reinforces efforts to ensure Indigenous self-determination and demonstrates Native students' ability to overcome long-standing educational inequities in school and beyond.