In the distance teaching institutions where e-learning initiatives are underway and where the planners and administrators grapple with effective adoption and deployment of technology-enabled education, faculty attitude and motivation assume considerable significance. Attitudinal pre-dispositions and institutional and allied barriers (including appropriate policy initiatives) are assumed to play a crucial role in making an effective shift from traditional distance education delivery to web-enabled education and training. Such issues are especially critical to single mode mega universities like the Indira Gandhi National Open University (IGNOU). This article reports the findings of a study conducted to examine the attitudes of faculty members from IGNOU towards e-learning, and to identify barriers and motivators of e-learning adoption and use. IGNOU, with about 1.5 million students scattered over 32 countries, has been offering e-learning programs for almost a decade. The findings suggest that extensive use of computers and email has a high relationship with positive attitudes towards e-learning. The most significant barriers perceived by the faculty included poor internet access by students and lack of training on e-learning, followed by institutional policy on and instructional design for e-learning. The important motivators included personal interest to use technology, intellectual challenge, and sufficient provision for technology infrastructure. (Contains 6 tables.)