ERIC Number: EJ957542
Record Type: Journal
Publication Date: 2008
Abstractor: As Provided
Neurodevelopmental Sequelae of Pediatric Acute Lymphoblastic Leukemia and Its Treatment
Janzen, Laura A.; Spiegler, Brenda J.
Developmental Disabilities Research Reviews, v14 n3 p185-195 2008
This review will describe the neurocognitive outcomes associated with pediatric acute lymphoblastic leukemia (ALL) and its treatment. The literature is reviewed with the aim of addressing methodological issues, treatment factors, risks and moderators, special populations, relationship to neuroimaging findings, and directions for future research. It is concluded that neurocognitive outcomes for the majority of children with standard-risk ALL treated according to current chemotherapy protocols is relatively good, but subgroups of children are more significantly compromised. As medical treatments advance and survival rates continue to improve, neurocognitive outcomes and other quality of life indicators will become increasingly important. Preventing or ameliorating treatment-related neuropsychological sequelae represents the next major challenge in pediatric ALL.
Descriptors: Quality of Life, Children, Cancer, Child Development, Neurological Organization, Neurological Impairments, Literature Reviews, Risk, Research Methodology, Outcomes of Treatment, Diagnostic Tests, Research Needs, Drug Therapy, Disabilities
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A