In this study, the researcher included an extensive science museum experience for the pre-service secondary science teachers within a "teaching methods course" to enhance their learning to teach science. The extensive museum experience covered four aspects: the visit, discussion with museum educators, the development of lesson plans, and practising teaching in the science museum. Twenty-one pre-service science teachers attended this course. Qualitative methods were used for data collection and analysis. The data sources included field notes, reports, diaries, and interviews. The findings show that this course connecting museum resources and context had created a novel situation for pre-service science teachers to learn how to teach science. The discourses with the museum educators also provided them with innovations in education beyond the gains from traditional teacher education. Through developing and practising teaching activities, they improved their understanding of the meanings and effective ways to use museum resources in science teaching. Pre-service science teachers reported that getting feedback from peers and observing modeling teaching was helpful. This course provided an alternative way to view how scientific activities were developed for junior high students. In general, the use of museum settings provides a new profile of learning and teaching course for pre-service science teachers in Taiwan. Based on the findings, this study makes suggestions for those science teacher educators who would like to use science museum resources and contexts to nurture prospective science teachers.