Effective practices for career counseling with gender variant individuals have yet to be identified for reasons that may include perceptions that the population is too small to warrant in-depth research, lack of funding for such efforts, and practitioners' lack of training and experience with transgender concerns. In this article, we describe the status of research and practice with respect to gender variant individuals. Definitions and terminology, vocational and workplace concerns, and vignettes of vocational and work-related situations that career counseling professionals may encounter when working with gender variant individuals are presented. Recommendations for practice, social advocacy, and future research are provided.