During a period when secularization poses many challenges to religiously affiliated colleges and universities, several key factors have been identified that can support these institutions in effectively meeting those challenges. This article identifies four of the principal drivers of secularization and how they have manifested themselves over the course of the 20th century. Those drivers are changes in the composition of university leadership, faculty, and student body; a push to comply with the accepted standards for academic excellence and the secularization of knowledge; a desire to be more like mainstream colleges and universities; and the need to accommodate growing religious pluralism in society. The article also identifies important actions that can support religiously affiliated postsecondary institutions in staying connected to their founding religious traditions. These factors include a clearly articulated vision for the institution that is based in the religious tradition, university leadership that is supportive of maintaining the connection between institution and religious tradition, and a strong campus culture based in the values of the religious tradition. The article then uses the experiences of Brigham Young University as an example of how these factors work together to counter secularization. The leadership decisions and actions taken by The Church of Jesus Christ of Latter-day Saints and Brigham Young University President Howard S. McDonald (1945-1949) are offered as a case study that may provide insights to other institutions at a time when trends in the United States continue to shift toward secularization.