Research Findings: This study examined preschool teachers' literal talk (LT) and inferential talk (IT) during shared book readings in early childhood education (ECE) and early childhood special education (ECSE) classrooms. We aimed to characterize and compare teachers' LT and IT in these 2 classroom contexts and determine whether differences in LT and IT are predicted by classroom type, teachers' educational background, or children's average language skills. We examined the shared book reading activities of 52 teachers (26 ECE classrooms, 26 ECSE classrooms). Results revealed that ECSE teachers used significantly more LT and showed more variability in their LT and IT than ECE teachers. ECSE classroom type predicted teachers' use of LT when we controlled for teacher education and children's language skills, whereas teacher education predicted teachers' use of IT when we controlled for classroom type and children's language skills. Practice or Policy: These findings have implications for best practice guidelines and policies, particularly for ECSE environments.