Integrating Task-Based Language Teaching (TBLT) and learning technologies can be the potential framework in designing language instruction to enhance learners' listening comprehension and speaking performance. However, not many past studies have explored how technology enhanced TBLT can enhance both listening comprehension and speaking performance of ESP learners. Therefore, the purpose of this study is to investigate the effects of TBLT on ESP learners' listening comprehension and speaking performance using a quasi-experiment with nonequivalent (pretest and posttest) control-group design. Ninety-seven ESP learners majoring in a Nursing program participated in the study. Four instruments were used for data collection, namely a listening section of TOEFL test, an online presentation, role-play, and online group discussion. Findings showed that technology implementation enhanced TBLT significantly influenced students' listening comprehension. In a similar vein, ESP learners' speaking performance based on role-play also had considerable improvement. However, concerning ESP learners' online presentations and online group discussions, their speaking performance scores did not improve significantly after receiving this experimental treatment. These findings shed some light on students' involvement in attaining multifarious language inputs related to their listening comprehension due to the authentic and technological learning materials and media. In considering speaking performance enhancement, ESP students could benefit from merging the role-play in ESP instruction with technology enhanced TBLT.