Tumescence in cadaveric dissection involves the introduction of fluid into interstitial spaces to assist in the separation of natural tissue planes and the preservation of delicate structures. With a hand surgeon's perspective, the senior author brought this technique into the cadaver lab. The infusion helped transform desiccated and adherent tissue into hydrated, mobile tissue, more like that of a living person. The use of the technique is described for dissecting the palms and soles, and the resulting dissections are demonstrated.