The Academic Skills Inventory (Kruger and Zechmeister, 2001) was developed at Loyola University of Chicago and originally designed for use with psychology majors. It was later extended for use in a variety of academic programs. The Academic Skills Inventory (ASI) assesses student self-reports of behaviors in 10 skill areas: (1) written and oral communication; (2) information gathering; (3) groups, organization, and community; (4) interpersonal skills, counseling, interviewing, and mentoring; (5) behavior management, supervision, and teaching; (6) individual differences, special populations, and cultural diversity; (7) critical thinking and problem solving; (8) research methodology and statistics; (9) ethics and values; and (10) technology and computers. In this article, the authors review its use by the Biology Department at James Madison University (JMU) to explore the impact of curricular changes on student perceptions of their academic skill development. Not all of the 10 skill areas would be expected to show differential impact for biology majors, but the authors certainly hoped to observe change in designated areas associated with science education.