This game was designed to provide students with an alternative way to learn biochemical pathways through an interactive approach. In this game, students worked in pairs to help each other identify pathways taped to each other's backs by asking simple "yes or no" questions related to these pathways. This exercise was conducted after the traditional biochemistry lectures on pathways and was designed to complement the lectures and reinforce key information about pathways. The advantage of this approach is that the pair of students was able to explore and experience two mechanisms of learning biochemical pathways. The Student t test performed on the students' pre-test and post-test scores indicated that students showed significant improvement on their abilities to identify pathways after participating in this game. (Contains 1 figure.)