Drawing upon a sample of 13,025 students who attended the nine majority minority colleges of the Los Angeles Community College District, this study examined the interaction effects of the racial composition of the colleges on student persistence. Special attention was given to variables that paired students' race to the racial demography of the campus (Majority African American, Majority Latino, or No Racial Majority). Multivariate regression analyses included a range of demographic, environmental, engagement, and satisfaction variables, and a measure of student persistence. Findings revealed multiple significant and varied results according to the pairing of student race to institutional composition. The effect sizes for these variables were small but consistent with those for academic preparation as reflected in the lowest level of math, English, and English as a Second Language (ESL) courses taken, and stronger than the effects for the engagement and satisfaction scales that we utilized. Implications for policy and practice are introduced and discussed.