The present study investigates the effect of online learning vs. blended learning (BL) in developing English language skills by nursing student. The participants of the study included sixty students of Asadabad Nursing Faculty. They were randomly divided into three groups. The control group received general English instruction through the communicative approach and did exercises based on the tasks for developing general English skills. The online group received general English instruction through LMS instructional model. The BL experimental group received general English instruction through blended learning instructional model. Students then took a posttest of standard general English (TOFEL). The results showed that the blended learning group performed better than the other groups in developing general English skills. These results have pedagogical implications for curriculum designers, developers of training programs for future nurses, material producers, and all who are involved in nursing education.