In various case-based training courses, such as engineering, science and medical courses, students need to learn not only the skills to deal with problems, but also the knowledge to identify problems and make correct decisions. Such educational objectives have been recognized by educators as being important but challenging. In this study, an RSI (Recognize, Summarize, Inquire)-based flipped classroom is proposed to achieve this aim. Moreover, an explorative study was designed to probe the effectiveness of the proposed approach in a nursing case-based training course. The case-handling performances of the students trained with the RSI-based flipped classroom and those trained with the conventional flipped classroom were compared. The findings reveal that the RSI-based flipped classroom promoted the students' learning achievement, self-efficacy, critical thinking, and satisfaction more than the conventional case-based training did.