Recent expansion of tertiary education in the Caribbean via the creation of two new universities invites reflection on what impedes the creation of research culture, and what enables it. We contend that research culture in the Caribbean comes up against the strictures of post-colonial dependence, university education in the region being largely a one-way traffic of ideas from metropolitan centers to island peripheries. To offset this, we call for change both in the external environments in which the universities are set, and their internal environments, within which the ethos of inquiry must become commonplace. Demand for research knowledge has to be cultivated throughout the Caribbean. Accordingly, we call for collaborative approaches between university communities and the various publics they serve, to find and solve problems that can lead to the improvement of well being.