Sexual minority individuals (lesbian, gay, bisexual, queer, and others; LGBQ+) have higher rates of mental health problems compared to heterosexual individuals (e.g., Rogers et al., 2021). Minority stress theory (Meyer, 2003) proposes that LGBQ+ individuals have higher rates of mental health problems due to the results of institutionalized prejudice in Western culture (i.e., sexual minority stress). The integration of intersectionality theory (Crenshaw, 1989) with minority stress theory has led to the vulnerability hypothesis: the notion that holding multiple minority statuses (e.g., gender, race, ethnicity) leads to increased vulnerability to experiences of minority stress due to holding multiple marginalized identities. Multiple studies have supported this hypothesis for LGBQ+ individuals, showing that LGBQ+ individuals who hold multiple minority identities report increased sexual minority stress experiences and/or greater mental health difficulties (e.g., Calabrese et al., 2015). However, to date, research has yet to assess the impact of multiple minority statuses concurrently on sexual minority stress. The present study evaluated how holding multiple minority statuses (gender, race, and ethnicity) related to sexual minority stress and, in turn, how sexual minority stress related to distress (depression and anxiety) and hazardous alcohol use in a sample of 2,203 LGBQ+ university students recruited from 20 public U.S. universities who completed two surveys six months apart. Mediation and moderated mediation analyses were conducted utilizing bootstrapping to estimate model paths. All three measures of sexual minority stress (felt sexual stigma, sexual self-stigma, and concealment of identity) were related to increased distress in cross-sectional and longitudinal analyses. Further, results indicated that holding certain minority identities was associated with increased risk for, or protection against, felt and/or sexual self-stigma, whereas others were associated with increased concealment. In particular, having a multisexual identity was related to lower felt/sexual self-stigma, but greater concealment. When considering gender, identifying as transgender and gender diverse was related to greater felt sexual stigma but lower sexual self-stigma, and identifying as a cisgender woman was related to lower sexual self-stigma. Finally, holding some racial minority identities were related to greater sexual self-stigma. Overall, a major implication of this study is that the relations among various minority identities and sexual minority stress for LGBQ+ individuals should not be oversimplified. Specifically, researchers should not assume that holding multiple minority statuses relates to increased risk for sexual minority stress across LGBQ+ populations. Future work should continue to evaluate the relations between multiple minority statuses among LGBQ+ individuals and sexual minority stress, including a focus on elucidating the complicated interrelationships between experiences of minority stress related to multiple minority identities (e.g., gender, sexuality, racial identity, ethnic identity, disability status). [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]