Successfully creating and implementing interdisciplinary curricula in introductory science, technology, engineering, and mathematics (STEM) courses is challenging, but doing so is increasingly more important as current problems in science become more interdisciplinary. Opening up the silos between science disciplines and overcoming common institutional barriers (cost, limited time, need to deliver specific course content, and lack of faculty commitment) is possible by bringing students together from different science courses to discuss interesting interdisciplinary problems. This article describes the mobilization and implementation of a community-oriented Interdisciplinary Science Seminar (ISS) that adds interdisciplinary content to traditional introductory science courses without a significant investment of additional resources. In addition, increased faculty collaboration on interdisciplinary curriculum was achieved, and a second new student-oriented interdisciplinary science program was created.