This multiple baseline across participants study examined the efficacy of a data-based individualization word study intervention for students with autism spectrum disorder (N=5) and low word reading skills. An experienced interventionist provided 1:1 word reading instruction in 30-minute sessions five times per week for an average of 10 sessions per participant. Intervention effects for directly taught words and words with similar spelling patterns were estimated using visual analysis and calculation of mean differences across baseline and intervention phases. Results indicate immediate and consistent improvements in word reading outcomes across all participants.