University faculty and community agencies collaborated to design and implement Healthy Weigh/El camino saludable, a family-focused obesity prevention and intervention program in a low-income, urban community at high risk for obesity and related chronic disease. Hispanic and African American families participated in 12 weekly sessions. Offered in English and Spanish, sessions included exercise classes, lessons based on Dietary Guidelines for Americans, and family meals with facilitated "table-talks" about how families were applying lesson content. Data were collected by interview and direct measurement. Participants demonstrated improved nutrition/exercise knowledge (p less than or equal to 0.01), dietary practices (92%), exercise patterns (54%), weight management (84%), and they attained individually determined goals (92%). Challenges, outcomes, and lessons learned in a community-campus partnership are described.