There are two major global educational trends that have changed the form and execution of humor in the classroom and in professional conferences: (1) the burgeoning instructional technology, especially PowerPoint, which can provide a vehicle for several forms of low risk humor anyone can present; and (2) the diversity of classroom demographics, especially students with different nationalities, which restricts the use of culture-specific humor. The first trend now "permits anyone to present humor without saying a word," much less a punchline. That means that any instructor, even one with the personality of a grapefruit, can deliver humor. The second trend draws a "line between culture-specific and culture-free humor." Instructors need to be particularly sensitive to the cultural composition of their classroom in choosing appropriate humor. When humor is intended for teaching, it is a teaching tool that is systematically-planned and has a specific learning outcome. The purposes of this groundbreaking article are: (1) to briefly review the research on humor and laughter; (2) to present a half dozen of the most effective techniques; (3) to suggest how and where to infuse humor throughout the use of a PowerPoint, (4) to list 40 safe, culture-specific and culture-free content topics for humor; and (5) to proffer a few final thoughts.