STEM (Science, Technology, Engineering, and Mathematics) education is an alternative learning approach to constructing 21st century skills. It encourages the emergence of innovation to develop these skills. The study uses a systematic literature review method adapted from Sharif and Moher "et al." using PRISMA. The content analysis aimed to systematically analyze trends in STEM or STEAM education research in Indonesia using articles published in national and international journals. From the inclusion criteria, there were 63 articles collected analyzed using the Paper Classification Form (PCF) instrument adapted from Kizilaslan "et al." with indicators title, author, author nation, journal name, year publishing, journal type, language, index, principal discipline, research method, data collection, sample, and data analysis. The findings indicate that the dominant topic is learning strategies with experimental research methods. STEM or STEAM education dominates at the secondary school level for science subjects. Project-based learning, problem-based learning, and Inquiry are the dominant learning models integrated with STEM or STEM learning. Critical thinking ability, scientific literacy, and learning outcomes are the dominant theme in STEM or STEAM education. Empirical research is needed on the potential of STEAM education to improve skills in 21st-century learning