The objective of this study was to examine associations between problem video game use and psychopathology. The Video Game Use Questionnaire (VGUQ) and the Symptom Checklist 90 (SCL-90) were administered in an international anonymous online survey. The VGUQ was used to identify problem video game users and SCL-90 assessed dimensions of psychopathology. In comparison with other video game players (n = 1789), those with problem video game use (n = 156) had significantly elevated scores on all SCL-90 subscales. When compared to the U.S. male nonpatients, a significantly greater proportion of male video game players exhibited higher levels of all psychopathology. These findings suggest that there is a non-specific relationship between various domains of psychopathology and video game use in general and problem video game use in particular.