Through the Minority Biomedical Research Support-Research Initiative for Scientific Enhancement program, the natural sciences faculty at Johnson C. Smith University, a historically Black university, works to support their students' learning. The heterogeneity of learning preferences among students challenges the faculty to provide a variety of instructional methods. Supplemental instruction was a particularly popular and effective strategy. Results include an increasing trend in number of JCSU Natural Sciences graduates. (Contains 3 figures.)